Psoriasis
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.[6] These skin patches are typically red, dry, itchy, and scaly.[3] On people with darker skin the patches may be purple in colour.[9] Psoriasis varies in severity from small, localized patches to complete body coverage.[3] Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.[10]
There are five main types of psoriasis: plaque, guttate, inverse, pustular, and erythrodermic.[6] Plaque psoriasis, also known as psoriasis vulgaris, makes up about 90 percent of cases.[4] It typically presents as red patches with white scales on top.[4] Areas of the body most commonly affected are the back of the forearms, shins, navel area, and scalp.[4] Guttate psoriasis has drop-shaped lesions.[6] Pustular psoriasis presents as small non-infectious pus-filled blisters.[11] Inverse psoriasis forms red patches in skin folds.[6] Erythrodermic psoriasis occurs when the rash becomes very widespread, and can develop from any of the other types.[4]Fingernails and toenails are affected in most people with psoriasis at some point in time.[4] This may include pits in the nails or changes in nail color.[4]
Psoriasis is generally thought to be a genetic disease that is triggered by environmental factors.[3] In twin studies, identical twins are three times more likely to be affected compared to non-identical twins. This suggests that genetic factors predispose to psoriasis.[4] Symptoms often worsen during winter and with certain medications, such as beta blockers or NSAIDs.[4] Infections and psychological stress can also play a role.[3][6]Psoriasis is not contagious.[4] The underlying mechanism involves the immune system reacting to skin cells.[4] Diagnosis is typically based on the signs and symptoms.[4]
There is no cure for psoriasis; however, various treatments can help control the symptoms.[4] These treatments include steroid creams, vitamin D3 cream, ultraviolet light and immune system suppressing medications, such as methotrexate.[6] About 75 percent of cases can be managed with creams alone.[4] The disease affects two to four percent of the population.[8] Men and women are affected with equal frequency.[6] The disease may begin at any age, but typically starts in adulthood.[5] Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, Crohn’s disease and depression.[4] Psoriatic arthritis affects up to 30 percent of individuals with psoriasis.[11]
Bronxville
Bronxville /ˈbrɒŋksvɪl/ is a suburban village in Westchester County, New York, located about 15 miles (24 km) north of midtown Manhattan.[3] It is part of the town of Eastchester. The village comprises 1 square mile (2.5 km2) of land in its entirety, approximately 20% of the town of Eastchester. As of the 2010 U.S. census, Bronxville had a population of 6,323.[4] As of 2014, it was ranked 18th in the state in median income.[5]
Millionaire real-estate and pharmaceutical mogul William Van Duzer Lawrence sparked the development of Bronxville as an affluent suburb of New York City with magnificent homes in a country-like setting.[6] The area, once known as “Underhill’s Crossing”, became “Bronxville” when the village was formally established. The population grew in the second half of the 19th century when railroads allowed commuters from Westchester County to work in New York City.[6] Lawrence’s influence can be seen throughout the community, including the historic Lawrence Park neighborhood, the Houlihan Lawrence Real Estate Corporation, and Lawrence Hospital. John F Kennedy, the president of the United States, also resided here for a time.[7]
The village was home to an arts colony in the early 20th century during which time many noteworthy houses by prominent and casual architects were built.[8] After the Bronx River Parkway was completed in 1925, the Village expanded rapidly with the construction of several apartment buildings and townhouses much of it built by the Lawrence family. As of 1959, they continued to own or manage 97% of the rental market.[9] In both rentals and ownership, the village discouraged and effectively prohibited Jewish residency, earning the name “The Holy Square Mile.”[9]