Squamous cell skin cancer
Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main types of skin cancer along with basal cell cancer, and melanoma.[10] It usually presents as a hard lump with a scaly top but can also form an ulcer.[1] Onset is often over months.[4] Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer.[11]
The greatest risk factor is high total exposure to ultraviolet radiation from the Sun.[2] Other risks include prior scars, chronic wounds, actinic keratosis, lighter skin, Bowen’s disease, arsenic exposure, radiation therapy, poor immune system function, previous basal cell carcinoma, and HPV infection.[2][12] Risk from UV radiation is related to total exposure, rather than early exposure.[13] Tanning beds are becoming another common source of ultraviolet radiation.[13] It begins from squamous cells found within the skin.[14] Diagnosis is often based on skin examination and confirmed by tissue biopsy.[2][3]
Decreasing exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing squamous-cell skin cancer.[5][6] Treatment is typically by surgical removal.[2] This can be by simple excision if the cancer is small otherwise Mohs surgery is generally recommended.[2] Other options may include application of cold and radiation therapy.[7] In the cases in which distant spread has occurred chemotherapy or biologic therapy may be used.[7]
As of 2015, about 2.2 million people have cSCC at any given time.[8] It makes up about 20% of all skin cancer cases.[15] About 12% of males and 7% of females in the United States developed cSCC at some point in time.[2] While prognosis is usually good, if distant spread occurs five-year survival is ~34%.[4][5] In 2015 it resulted in about 51,900 deaths globally.[9] The usual age at diagnosis is around 66.[4] Following the successful treatment of one case of cSCC people are at high risk of developing further cases.[2]
Bronxville
Bronxville /ˈbrɒŋksvɪl/ is a suburban village in Westchester County, New York, located about 15 miles (24 km) north of midtown Manhattan.[3] It is part of the town of Eastchester. The village comprises 1 square mile (2.5 km2) of land in its entirety, approximately 20% of the town of Eastchester. As of the 2010 U.S. census, Bronxville had a population of 6,323.[4] As of 2014, it was ranked 18th in the state in median income.[5]
Millionaire real-estate and pharmaceutical mogul William Van Duzer Lawrence sparked the development of Bronxville as an affluent suburb of New York City with magnificent homes in a country-like setting.[6] The area, once known as “Underhill’s Crossing”, became “Bronxville” when the village was formally established. The population grew in the second half of the 19th century when railroads allowed commuters from Westchester County to work in New York City.[6] Lawrence’s influence can be seen throughout the community, including the historic Lawrence Park neighborhood, the Houlihan Lawrence Real Estate Corporation, and Lawrence Hospital. John F Kennedy, the president of the United States, also resided here for a time.[7]
The village was home to an arts colony in the early 20th century during which time many noteworthy houses by prominent and casual architects were built.[8] After the Bronx River Parkway was completed in 1925, the Village expanded rapidly with the construction of several apartment buildings and townhouses much of it built by the Lawrence family. As of 1959, they continued to own or manage 97% of the rental market.[9] In both rentals and ownership, the village discouraged and effectively prohibited Jewish residency, earning the name “The Holy Square Mile.”[9]